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RTOG 1304 / B-51
RTOG 1304 / B-51: A Randomized Phase III Clinical
Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and
Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary
Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically
Negative Axillary Nodes After Neoadjuvant Chemotherapy
The
main purpose of this clinical trial is to study women who have cancer cells in
the lymph nodes at the time that the breast cancer is diagnosed and have
chemotherapy before surgery that clears the cancer cells from the lymph
nodes. This study asks 1) if, after lumpectomy, radiation to the breast
and lymph nodes will be better than radiation only to the breast at keeping
breast cancer from returning, and 2) if, after mastectomy, radiation to the
area where the breast used to be and to the lymph nodes is better than no
radiation at keeping breast cancer from returning. This study also
asks whether giving radiation as described above will help women live longer.
This study will also help researchers learn about how the study treatment
affects your quality of life. Quality of life is your physical and
emotional well-being.
Principal Investigator:
Dr. Jordan Maier, MD
Contact:
Study Coordinator
Phone (Main): 810-342-3846
IRB Number:
2016-00029
clinicaltrials.gov:
01872975
More Information: