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The information contained on this page is provided as general health information and is not intended to substitute as medical advice and direction from your physician or health care provider. Please direct any questions related to your health care provider. In an emergency, call 9-1-1 or go to the nearest emergency center.

Birth control medications - monophasic, biphasic, and triphasic preparations

Selected Medications

Monophasic, biphasic, and triphasic preparations of birth control medications include:

  • Dienogest and Estradiol valerate (Natazia)
  • Drospirenone and Ethinyl Estradiol (Gianvi, Loryna, Ocella, Syeda, Vestura, Yasmin, Yaz, Zarah)
  • Drosipirenone, Ethinyl Estradiol and Levomefolate (Beyaz, Sayral)
  • Ethinyl Estradiol and Desogestrel (Apri, Desogen, Mircette, and Ortho-Cept)
  • Ethinyl Estradiol and Ethynodiol diacetate
  • Ethinyl Estradiol and Norethindrone acetate
  • Ethynodiol and Ethinyl Estradiol (Kelnor, Zovia 1/35, Zovia 1/50)
  • Ethinyl Estradiol and Levonorgestrel (Alesse, Levlen, Levlite, Levora, Nordette, PREVEN, Tri-Levlen, and Triphasil)
  • Ethinyl Estradiol and Norethindrone (Brevicon, Estrostep 21, Estrostep Fe, Femhrt, Genora 0.5/35, Genora 1/35, Jenest-28, Loestrin, Modicon, Nelova 0.5/35E, Nelova 10/11, Norethin 1/35E, Norinyl 1+35, Ortho-Novum 1/35, Ortho-Novum 10/11, Ortho-Novum 7/7/7, Ovcon 35, Ovcon 50, and Tri-Norinyl)
  • Ethinyl Estradiol and Norgestimate (Ortho Tri-Cyclen, Ortho-Cyclen, and Ortho-Prefest)
  • Mestranol and Norethindrone (Necon1/50, Norinyl 1/50, Ortho-Novum 1/50
  • Norgestrel and Ethinyl Estradiol


Vitamin B9 (Folic Acid)

Taking birth control medications- monophasic, biphasic, and triphasic may deplete vitamin B9 (folic acid)

Low levels of folic acid in the body may be linked to:

  • Anemia
  • Heart disease
  • Birth defects

Symptoms may include:

  • Weakness
  • Mouth sores
  • Swollen tongue
  • Depression
  • Poor growth

Editorial Note

The information presented here covers some of the nutrients that may be affected when you take certain medicines. If you have any of these signs and symptoms, it does not always mean you have low levels of these nutrients.

Factors that affect the level of nutrients are:

  • Your medical history
  • Diet
  • Lifestyle
  • How long you have been taking the medicine

Please talk to your health care provider. They can best address your health care needs and see if you are at risk for low levels of any nutrients.

Supporting Research

Gold Standard Drug Database: First Consult: Contraception, 2012.!/content/medical_topic/21-s2.0-1057579. Accessed July 19, 2016.

Sachdev HPS, Shah D. Vitamin B complex deficiencies and excess. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016:chap 49.

Shenkin A, Roberts NB. Vitamins and trace elements. In: Burtis CA, Ashwood ER, Bruns DE, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 5th ed. St. Louis, MO: Elsevier Saunders; 2012:chap 31.