search buttonmobile navigation expand button

The information contained on this page is provided as general health information and is not intended to substitute as medical advice and direction from your physician or health care provider. Please direct any questions related to your health care provider. In an emergency, call 9-1-1 or go to the nearest emergency center.


Hereditary amyloidosis

Definition

Hereditary amyloidosis is a condition in which abnormal protein deposits (called amyloid) form in almost every tissue in the body. Deposits most often form in the heart, kidneys, and nervous system. These protein deposits damage the tissues and interfere with how organs work.

Alternative Names

Amyloidosis - hereditary; Familial amyloidosis

Causes

Hereditary amyloidosis is passed down from parents to their children (inherited). Genes may also play a role in primary amyloidosis.

Other types of amyloidosis are not inherited. They include:

  • Senile systemic: seen in people older than 70
  • Spontaneous: occurs without a known cause
  • Secondary: results from diseases such as cancer of the blood cells (myeloma)

Specific conditions include:

Treatment

A liver transplant may be helpful. Talk to your health care provider about treatments.

visHeader

Amyloidosis on the fingers

References

Gertz MA. Amyloidosis. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 188.

Budd RC, Seldin DC. Amyloidosis. In: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O’Dell JR, eds. Kelley and Firestein's Textbook of Rheumatology. 10th ed. Philadelphia, PA: Elsevier; 2017:chap 116.