Primary Objectives:
Secondary Objectives:
ii. Prolymphocytes comprising ≤ 55% of blood lymphocytes. iii. Presence of ≥ 5 × 109 B lymphocytes/L (5000/µL) in the peripheral blood (at any point since initial diagnosis).
ii. Significant fatigue (inability to work or perform usual activities). iii. Fevers higher than 100.5°F or 38.0°C for ≥ 2 weeks before Screening without evidence of infection.
iv. Night sweats for > 1 month before Screening without evidence of infection.
OR
≥ 30 mL/min as calculated using the Cockcroft Gault formula and not dialysis-dependent.